Planar cell polarity (PCP) and neural tube defects (NTDs) are linked, with a subset of NTD
patients found to harbor mutations in PCP genes, but there is limited data on whether these …

Neural tube defects (NTDs) are a heterogeneous group of common severe congenital
anomalies which affect 1–2 infants per 1000 births. Most genetic and/or environmental …

Abstract Background Neural tube defects (NTDs) are common birth defects (~ 1 in 1000
pregnancies in the US and Europe) that have complex origins, including environmental and …

Neural tube defects are common and serious human congenital anomalies. These
malformations have a multifactorial etiology and can be reproduced in mouse models by …

The vertebrate central nervous system is a hollow structure that develops first as a flat sheet
of cells and subsequently rolls into a tube during embryogenesis. Failure of this rolling …

Background Neural tube defects (NTDs) are among the most common congenital defects
affecting approximately 1 in 1000 live births in North America. Their etiology is complex …

Neural tube defects (NTD), including anencephaly and spina bifida, are a group of severe
congenital abnormalities in which the future brain and/or spinal cord fail to close. In mice …

The neural tube is the first critically important structure that develops in the embryo. It serves
as the primordium of the central nervous system; therefore, the proper formation of the …

Neural tube closure (neurulation) is a complex process involving many cell phenomena.
Both extrinsic and intrinsic forces are essential to elevate the neural plate into the neural …

Although most neural tube defects (anencephaly, spina bifida) occur as isolated
malformations, a substantial proportion are attributable to chromosome anomalies, known …