The developmental process of neurulation involves a series of coordinated morphological
events, which result in conversion of the flat neural plate into the neural tube, the primordium …

The mechanism (s) behind folate rescue of neural tube closure are not well understood. In
this study we show that maternal intake of folate prior to conception reverses the proliferation …

Neural tube defects (NTDs) are severe malformations of the central nervous system,
affecting 1 of 1,000 live births. Mouse models were instrumental in defining the signaling …

Neural tube defects (NTDs), including spina bifida and anencephaly, are among the most
common birth defects worldwide, but their underlying genetic and cellular causes are not …

Neural tube defects are severe congenital malformations affecting around one in every 1000
pregnancies. An innovation in clinical management has come from the finding that closure of …

Inactivation of the murine folate binding protein-1 (Folbp1) has been shown to play a vital
role in embryonic development. Nullizygous embryos (Folbp1−/−) have significant …

Curtailed (Tc), a dominant mutation on mouse chromosome 17, causes a tailless phenotype
and occasional hindlimb paralysis in heterozygotes. Histologically, Tc/+ embryos show a …

Studies of the cell biology of neurulation have revealed that a set of coordinated types of cell
behaviour-change in cell shape, cell movement and cell proliferation-are pivotal in …

The epidemiological investigation of the common open neural tube defects (NTDs),
anencephaly, and spina bifida, has a long history. The most significant finding from these …

Neural tube defects are severe malformations affecting 1/1,000 live births. The planar cell
polarity pathway controls the neural tube closure and has been implicated in the …