Gastrulation and neurulation are successive morphogenetic processes that play key roles in
shaping the basic embryonic body plan. Importantly, they operate through common cellular …

Abstract Background Neural tube defects (NTDs) are common congenital malformations
resulting in failure of the neural tube closure during early embryonic development. Although …

A proportion of neural tube defects (NTDs) can be prevented by maternal folic acid
supplementation, although some cases are unresponsive. The curly tail mutant mouse …

Spina bifida is one of the most common neural tube defects (NTDs) with a complex etiology.
Variants in planar cell polarity (PCP) genes have been associated with NTDs including …

Infants with neural tube defects (NTDs) often have associated congenital anomalies. The
reported frequency and types of associated malformations vary between different studies …

The last stage of neural tube (NT) formation involves closure of the caudal neural plate (NP),
an embryonic structure formed by neuromesodermal progenitors and newly differentiated …

Neurulation is a morphogenetic event par excellence. During this highly choreographed four-
dimensional process, a flat sheet of ectoderm is transformed into an elongated tubular …

The planar cell polarity (PCP) pathway controls the process of convergent extension (CE)
during gastrulation and neural tube closure, and has been implicated in the pathogenesis of …

Neural tube defects (NTDs) constitute the second most frequent cause of human congenital
abnormalities. Complex multigenetic causes have been suggested to contribute to NTDs …

We present evidence for multisite NT closure in humans with representative examples of
types of NTDs that would be expected if NT closure in humans is similar to experimental …