Development of new tuberculosis drugs: translation to regimen composition for drug-sensitive and multidrug-resistant tuberculosis
Tuberculosis (TB) kills more people than any other infectious disease. Challenges for
developing better treatments include the complex pathology due to within-host immune …
developing better treatments include the complex pathology due to within-host immune …
Anti-tuberculosis treatment strategies and drug development: challenges and priorities
VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …
biological uncertainties remain and hamper progress. However, owing to collaborative …
Advancing the development of new tuberculosis treatment regimens: the essential role of translational and clinical pharmacology and microbiology
KE Dooley, D Hanna, V Mave, K Eisenach… - PLoS …, 2019 - journals.plos.org
Application of clinical pharmacology best practices is essential to the efficient and rational
development of drugs. In general, knowledge gained about exposure–response …
development of drugs. In general, knowledge gained about exposure–response …
Challenges in the clinical assessment of novel tuberculosis drugs
To tackle the global TB epidemic effectively, novel treatment strategies are critically needed
to shorten the duration of TB therapy and treat drug-resistant TB. Drug development for TB …
to shorten the duration of TB therapy and treat drug-resistant TB. Drug development for TB …
A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis
Introduction: Understanding drug exposure at disease target sites is pivotal to profiling new
drug candidates in terms of tolerability and efficacy. Such quantification is particularly …
drug candidates in terms of tolerability and efficacy. Such quantification is particularly …
Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: a mechanistic model and tool for regimen and dose optimization
Background The sites of mycobacterial infection in the lungs of tuberculosis (TB) patients
have complex structures and poor vascularization, which obstructs drug distribution to these …
have complex structures and poor vascularization, which obstructs drug distribution to these …
Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis
Standard treatment for active tuberculosis (TB) requires drug treatment with at least four
drugs over six months. Shorter-duration therapy would mean less need for strict adherence …
drugs over six months. Shorter-duration therapy would mean less need for strict adherence …
Systematic measurement of combination-drug landscapes to predict in vivo treatment outcomes for tuberculosis
Lengthy multidrug chemotherapy is required to achieve a durable cure in tuberculosis.
However, we lack well-validated, high-throughput in vitro models that predict animal …
However, we lack well-validated, high-throughput in vitro models that predict animal …
Population pharmacokinetics and Bayesian dose adjustment to advance TDM of anti-TB drugs
MGG Sturkenboom, AG Märtson, EM Svensson… - Clinical …, 2021 - Springer
Tuberculosis (TB) is still the number one cause of death due to an infectious disease.
Pharmacokinetics and pharmacodynamics of anti-TB drugs are key in the optimization of TB …
Pharmacokinetics and pharmacodynamics of anti-TB drugs are key in the optimization of TB …
Understanding pharmacokinetics to improve tuberculosis treatment outcome
J Reynolds, SK Heysell - Expert opinion on drug metabolism & …, 2014 - Taylor & Francis
Introduction: Tuberculosis (TB) remains the leading cause of death from a curable infectious
disease; drug-resistant TB threatens to dismantle all prior gains in global control. Suboptimal …
disease; drug-resistant TB threatens to dismantle all prior gains in global control. Suboptimal …
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