Preclinical data suggest that one method of inducing autoimmunity to tumor is the
administration and subsequent withdrawal of cyclosporine A following chemotherapy and …

PURPOSE To evaluate the antitumor activity and toxicity of concurrent biochemotherapy that
uses cisplatin, vinblastine, and docarbazine (DTIC)(CVD) in combination with interferon alfa …

A phase II trial was conducted to determine the efficacy and toxicity of the addition of
interferon-[alpha] 2b (IFN-a [alpha]) to the chemotherapy combination of dacarbazine …

PURPOSE To evaluate the antitumor activity of combination cisplatin (CDDP) and alpha-
interferon (alpha-IFN) in advanced, measurable metastatic melanoma. PATIENTS AND …

Since cytotoxic chemotherapy (BCNU, DTIC and cisplatin, tamoxifen) and interferon-
[alpha](IFN-[alpha]) have each produced responses in advanced malignant melanoma, a …

The purpose of this trial was to determine the toxicity and antineoplastic activity of cisplatin,
carboplatin, tamoxifen, and interferon-α (IFN-α) in patients with advanced melanoma. Eleven …

Background Metastatic melanoma is commonly treated with chemotherapy and/or biological
agents used separately. In this study we have investigated the efficacy of combined …

The majority of patients with stage I melanoma can be cured with surgery. Extension of
tumor to the regional lymph nodes portends a poor prognosis, with an expected 5-year …

The antitumor activity of available chemotherapy regimens against advanced melanoma is
modest. Likewise, the results with biologic response modifiers such as interleukin-2 (IL-2) …

Twenty-nine patients with metastatic malignant melanoma were treated with cyclocytidine,
240 mg/m²/day sc for 10 days. All patients had received extensive prior chemotherapy. Only …