Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) characterized by a type 2
immune signature often have severe and recurrent disease. Lower airway conditions such …

With the increasing recognition of the role of type 2 immune responses in chronic
rhinosinusitis, its severity, recurrence, and comorbidities, several biologics targeting IL-4, IL …

The development of biologics targeting various aspects of type 2 inflammation for the
treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) will provide clinicians with …

In western countries, 85% of chronic rhinosinusitis with nasal polyp disease reveals a type 2
inflammatory pattern with expression of IL-4,-5, and-13 as well as increased concentrations …

Background Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and asthma are
strongly associated, and patients suffering from both diseases are often difficult to treat …

Chronic rhinosinusitis (CRS) is a prevalent and heterogeneous disease associated with a
high degree of morbidity. Although there exist specific conditions for diagnosis, it has been …

Background: The management of chronic rhinosinusitis with nasal polyps (CRSwNP) is
evolving, with an emphasis on treating the underlying type 2 inflammation. Objective: The …

Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have coexisting
asthma under the concept of “United Airway Disease”, being the combination of both …

Background Biologic medications are emerging as options for treating chronic rhinosinusitis
with nasal polyps (CRSwNP). Several questions remain regarding patient selection …

Background The clinical approach to upper and lower respiratory diseases from a joint
perspective, known as united airways disease (UAD), is challenging for health care …