Environmental toxicants and male reproductive function

CY Cheng, EWP Wong, PPY Lie, MWM Li, L Su… - …, 2011 - Taylor & Francis
Environmental toxicants, such as cadmium and bisphenol A (BPA) are endocrine disruptors.
In utero, perinatal, or neonatal exposure of BPA to rats affect the male reproductive function …

Environmental contaminants: Is male reproductive health at risk?

DD Mruk, CY Cheng - Spermatogenesis, 2011 - Taylor & Francis
Contaminants such as cadmium, bisphenol A and lead which pollute our environment affect
male reproductive function. There is evidence that toxicant exposure adversely affects …

Impacts of environmental toxicants on male reproductive dysfunction

EWP Wong, CY Cheng - Trends in pharmacological sciences, 2011 - cell.com
Male infertility caused by exposure to environmental toxicants such as cadmium, mercury,
bisphenol A (BPA) and dioxin is a global problem, particularly in industrialized countries …

Bisphenol A damages testicular junctional proteins transgenerationally in mice

EO Adegoke, MS Rahman, S Amjad, WK Pang… - Environmental …, 2022 - Elsevier
Testicular junctions are pivotal to male fertility and regulated by constituent proteins.
Increasing evidence suggests that environmental chemicals, including bisphenol A (BPA) …

The apical ES–BTB–BM functional axis is an emerging target for toxicant-induced infertility

HT Wan, DD Mruk, CKC Wong, CY Cheng - Trends in molecular medicine, 2013 - cell.com
Testes are sensitive to toxicants, such as cadmium and phthalates, which disrupt a local
functional axis in the seminiferous epithelium known as the 'apical ectoplasmic …

Cadmium-induced testicular injury

ER Siu, DD Mruk, CS Porto, CY Cheng - Toxicology and applied …, 2009 - Elsevier
Cadmium (Cd) is an environmental toxicant and an endocrine disruptor in humans and
rodents. Several organs (eg, kidney, liver) are affected by Cd and recent studies have …

Cadmium-induced Sertoli Cell Injury Through p38-MAPK and Related Signaling Proteins—A Study by RNA Sequencing

L Wang, X Li, T Bu, X Wu, L Li, S Gao, D Yun… - …, 2023 - academic.oup.com
Environmental toxicants, such as cadmium, found in foods, water, and consumer products
are known to induce male reproductive dysfunction. However, the underlying molecular …

Mitogen-activated protein kinases in male reproductive function

MWM Li, DD Mruk, CY Cheng - Trends in molecular medicine, 2009 - cell.com
Recent studies have shown that male reproductive function is modulated via the mitogen-
activated protein kinase (MAPK) cascade. The MAPK cascade is involved in numerous male …

Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis

S Salian, T Doshi, G Vanage - Toxicology, 2009 - Elsevier
BACKGROUND: Sertoli cell junctional proteins (SCJP)(viz. adhesion, gap and tight
junctions) are important for spermatogenesis and perturbations in expression of these …

Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?

N Li, DD Mruk, WM Lee, CKC Wong… - Seminars in Cell & …, 2016 - Elsevier
Sertoli cells isolated from rodents or humans and cultured in vitro are known to establish a
functional tight junction (TJ)-permeability barrier that mimics the blood–testis barrier (BTB) in …