We have used multiple-amino acid replacement mutagenesis to examine the roles of the
TCR homologues of Ig complementarity-determining regions (CDR) and framework …

A defining characteristic of superantigens is their ability to stimulate T cells based
predominantly on the type of variable segment of the T cell receptor (TCR) beta chain (V …

The interaction of the T-cell receptor (TCR) with peptide antigen plus major
histocompatibility complex (MHC) protein requires both alpha and beta chains of the TCR …

Bacterial toxin superantigens bind to MHC class II molecules and activate a large proportion
of T cells through a direct interaction with the T cell receptor (TCR). The toxin: TCR …

CD4 T cell receptors (TCRs) recognize antigenic peptides presented by self major
histocompatibility complex (MHC) class II molecules as well as non-self MHC class II …

To investigate the structural and genetic basis of the T cell response to defined
peptide/major histocompatibility (MHC) class II complexes in humans, we established a …

THE αβ T-cell antigen receptor (TCR) recognizes antigenic peptides in the context of self
major histocompatibility complex (MHC) molecules1–4. The specificity of recognition of MHC …

While recent evidence strongly suggests that the third complementarity determining regions
(CDR3s) of T cell receptors (TCRs) directly contact antigenic peptides bound to major …

Superantigen recognition by some T cells is strongly influenced by polymorphic residues of
the MHC class II molecule, suggesting that the TCR contacts the class II molecule during …

The T-cell antigen receptor (TCR) is a heterodimeric structure composed of highly variable a
and^ chains. Foreign antigens are presented to the TCR in the form of short peptides bound …