Objective Recent availability of amyloid and tau positron emission tomography (PET) has
provided us with a unique opportunity to measure the association of systemic vascular …

Objective To investigate the associations between age, vascular health, and Alzheimer
disease (AD) imaging biomarkers in an elderly sample. Methods We identified 430 …

While cerebrovascular disease can be observed in vivo using MRI, the multiplicity and
heterogeneity in the mechanisms of cerebrovascular damage impede accounting for these …

Tau pathology and vascular dysfunction are important contributors to Alzheimer's disease
(AD), but vascular–tau associations and their effects on cognition are poorly understood. We …

Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

Cerebrovascular disease (CVD) manifests through a broad spectrum of mechanisms that
negatively impact brain and cognitive health. Oftentimes, CVD changes (excluding acute …

Objective Neuropathological studies have demonstrated that cerebrovascular disease and
Alzheimer disease (AD) pathology frequently co‐occur in older adults. The extent to which …

Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is
thought to play a role in the pathogenesis of cognitive disorders. Identifying the etiologies of …

Objective To investigate the multifactorial processes underlying cognitive aging based on
the hypothesis that multiple causal pathways and mechanisms (amyloid, vascular, and …

Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …