In adult skin wounds, collagen expression rapidly re-establishes the skin barrier, although
the resultant scar is aesthetically and functionally inferior to unwounded tissue. Although …

Impaired wound healing is a major source of morbidity in diabetic patients. Poor outcome
has, in part, been related to increased inflammation, poor angiogenesis, and deficiencies in …

Adipose tissue secretes adipocytokines for energy homeostasis, but recent evidence
indicates that some adipocytokines also have a profound local impact on wound healing …

A dynamic cell-matrix interaction is crucial for a rapid cellular response to changes in the
environment. Appropriate cell behavior in response to the changing wound environment is …

Proliferation and migration of epidermal stem cells (EpSCs) are essential for epithelialization
during skin wound healing. Angiopoietin-like 4 (ANGPTL4) has been reported to play an …

VEGF and Angiopoietin (Ang) 1 are growth factors that independently improve wound
healing outcomes. Using a tet-repressible mouse model coupled with streptozotocin …

The process of wound healing involves a complex and vast interplay of growth factors and
cytokines that coordinate the recruitment and interaction of various cell types. A series of …

From the moment we are born, every injury to the skin has the potential to form a scar, many
of which can impair form and/or function. As such, scar management constitutes a billion …

The persistent inflammatory response at the wound site is a cardinal feature of nonhealing
wounds. Prolonged neutrophil presence in the wound site due to failed clearance by …

Diabetes mellitus (DM) is one of the severe metabolic disorders of carbohydrate metabolism
worldwide. Developing countries are at higher risk of DM, and there is significant evidence …