The HO-1 isoenzyme is an early stress response gene regulated by many forms of oxidative
stress. The HO-2 isoenzyme is predominantly a constitutive enzyme, which may serve to …

Heme Oxygenase is the rate-limiting enzyme in the degradation of heme into carbon
monoxide (CO), iron and bilirubin. To date, three heme oxygenase isozymes have been …

Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to biologically active products:
carbon monoxide (CO), biliverdin, and ferrous iron. It participates in maintaining cellular …

The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

The microsomal heme oxygenase system consists of heme oxygenase (HO) and NADPH–
cytochrome P450 reductase, and plays a key role in the physiological catabolism of heme …

Organisms on our planet have evolved in an oxidizing environment that is intrinsically
inimical to life, and cells have been forced to devise means of protecting themselves. One of …

This review is intended to stimulate interest in the effect of increased expression of heme
oxygenase-1 (HO-1) protein and increased levels of HO activity on normal and pathological …

抄録 Heme oxygenase (HO) catalyzes the rate-limiting step in heme degradation to produce
carbon monoxide (CO), iron, and biliverdin. Biliverdin is subsequently converted to bilirubin …

The aim of this review is to highlight the advances in the field of heme oxygenase-1 (HO-1)
inhibitors over the past years, particularly from a medicinal chemistry point of view; …

Heme oxygenases (HOs) are the rate-limiting enzymes in the catabolism of heme into
biliverdin, free iron, and carbon monoxide. Two genetically distinct isoforms of HO have …