Heme oxygenase (HO) catalyzes degradation of heme to biliverdin, iron, and carbon
monoxide. It consists of three isoforms: an inducible form (HO-1), a constitutive form (HO-2) …

Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in
response to a variety of stimuli to degrade heme, which generates the biologically active …

Oxidative stresses such as oxidant stimuli, inflammation, exposure to xenobiotics, or ionizing
irradiation provoke cellular protective responses, principally involving transcriptional …

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …

This Forum issue “Heme Oxygenase”(HO) includes original research articles and reviews
that are aimed at understanding the role of HO-1 in several pathophysiological conditions …

Abstract Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO,
plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …

Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is an integral
membrane protein of the smooth endoplasmic reticulum. However, we detected an HO-1 …

Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative
conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is …

Heme oxygenase (HO) is the rate‐limiting enzyme in the catabolism of heme, followed by
production of biliverdin, free iron and carbon monoxide (CO). Three mammalian HO …

The ability of iron to accept or donate electrons, coupled with the ability of oxygen to act as
an electron acceptor, renders both elements essential to normal cellular biology. However …