[HTML][HTML] Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress
MG Battelli, L Polito, A Bolognesi - Atherosclerosis, 2014 - Elsevier
Endothelial xanthine oxidoreductase (XOR) together with NAD (P) H oxidase and nitric
oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO …
oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO …
[HTML][HTML] Pathophysiology of circulating xanthine oxidoreductase: new emerging roles for a multi-tasking enzyme
MG Battelli, A Bolognesi, L Polito - … Acta (BBA)-Molecular Basis of Disease, 2014 - Elsevier
The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …
[HTML][HTML] The role of xanthine oxidoreductase and uric acid in metabolic syndrome
Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome
through the oxidative stress and the inflammatory response induced by XOR-derived …
through the oxidative stress and the inflammatory response induced by XOR-derived …
[HTML][HTML] Xanthine oxidoreductase: One enzyme for multiple physiological tasks
Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from
a complicated evolutionary process that assigned it many physiological roles. The main …
a complicated evolutionary process that assigned it many physiological roles. The main …
The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction
A Meneshian, GB Bulkley - Microcirculation, 2002 - Wiley Online Library
Xanthine oxidoreductase (XOR) is a ubiquitous metalloflavoprotein that appears in two
interconvertible yet functionally distinct forms: xanthine dehydrogenase (XD), which is …
interconvertible yet functionally distinct forms: xanthine dehydrogenase (XD), which is …
A new paradigm for XOR-catalyzed reactive species generation in the endothelium
EE Kelley - Pharmacological Reports, 2015 - Springer
A plethora of vascular pathology is associated with inflammation, hypoxia and elevated rates
of reactive species generation. A critical source of these reactive species is the purine …
of reactive species generation. A critical source of these reactive species is the purine …
[HTML][HTML] Metabolic syndrome and cancer risk: the role of xanthine oxidoreductase
Obesity and related pathologies such as diabetes and metabolic syndrome are associated
with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is …
with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is …
[HTML][HTML] Binding of xanthine oxidase to vascular endothelium: kinetic characterization and oxidative impairment of nitric oxide-dependent signaling
M Houston, A Estevez, P Chumley, M Aslan… - Journal of Biological …, 1999 - ASBMB
Concentrations of up to 1.5 milliunits/ml xanthine oxidase (XO)(1.1 μg/ml) are found
circulating in plasma during diverse inflammatory events. The saturable, high affinity binding …
circulating in plasma during diverse inflammatory events. The saturable, high affinity binding …
Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications
CE Berry, JM Hare - The Journal of physiology, 2004 - Wiley Online Library
There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …
cardiovascular disease. Biochemical, molecular and pharmacological studies further …
Vascular oxidative stress, nitric oxide and atherosclerosis
H Li, S Horke, U Förstermann - Atherosclerosis, 2014 - Elsevier
In the vascular wall, reactive oxygen species (ROS) are produced by several enzyme
systems including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide …
systems including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide …
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