The aim of the present study was to establish the gene frequency of six polymorphisms of
the ABCB1, CYP3A5, CYP2C19, and P2RY12 genes in a population resident of Mexico City …

Background Recent studies have reported the clinical importance of CYP2C19 and ABCB1
polymorphisms in an individualized approach to clopidogrel treatment. The aims of this …

Clopidogrel is an antiplatelet drug used to prevent recurrent ischemic events after acute
coronary syndrome and/or coronary stent implantation. Single nucleotide polymorphisms …

Methods: Healthy adults (n= 90) of either gender were administered single dose of 300 mg
clopidogrel. Baseline, 4 h postdose, and day 7 assessment of platelet aggregation and …

Background Clopidogrel is a pro-drug and its intestinal absorption is limited by the P-
glycoprotein encoded by the ABCB1 gene. It is metabolized hepatically by cytochrome P450 …

This study was aimed to investigate the potential differences in allele frequencies of the
CYP2B6 gene between Spaniards and Central Americans. Three single nucleotide …

Resumen CEDILLO-SALAZAR, Félix R. et al. Association of CYP2C19* 2 polymorphism with
clopidogrel resistance among patients with high cardiovascular risk in Northeastern Mexico …

Polymorphisms in CYP3A genes, such as CYP3A5} and CYP3A4, as well as in the MDR1
gene, which encodes for P-glycoprotein, have been implicated as genetic markers in several …

The most widely studied polymorphisms of the ABCB1 gene are rs1128503 (c. 1236C> T),
rs2032582 (c. 2677G> T/A), and rs1045642 (c. 3435C> T). Although variation in ABCB1 …

Objective: To investigate the association between CYP2C19 and ABCB1 polymorphisms
and clopidogrel resistance (CR) in patients with cardiovascular disease in Beijing district …