Differences in metabolism of drugs can lead to severe toxicity or therapeutic failure. In
addition to cytochrome P450 2D6, which plays a critical role in drug metabolism, ABCB1 …

Aims/objective Influence of genetic variations on the response of clopidogrel, an antiplatelet
drug is implicated. In the present study, the prevalence of single nucleotide polymorphisms …

CYP2C19* 2 allele is related to resistance to the antiplatelet effect of CLO” 1. Indeed, the
CYP2C19* 2 polymorphism can result in molecular change, and this can further result in …

The goal of this study was to detect genotypic differences between Spaniards and other
related populations regarding CYP3A4* 1B, CYP3A5* 3, and ABCB1 (MDR1) C3435T …

Objective To investigate the frequency of CYP2C19 polymorphisms involved in clopidogrel
metabolism in Fujian Han population. Methods Frequencies of CYP2C19* 2, CYP2C19* 3 …

Backgrounds and objectives Clopidogrel, an inhibitor of platelet ADP P2Y12 receptors,
plays an important role in the prevention of stent thrombosis. However, some patients do not …

Genetic variation in the cytochrome P450 2C19 (CYP2C19) gene has been documented
gradually as the determinant conversion and variability in the antiplatelet effect of …

Clopidogrel is one of the most commonly prescribed drugs, as its combination with low-dose
aspirin is the recommended oral anti-platelet therapy, to prevent ischaemic events following …

In contrast to the* 2 variant, the* 17 variant has been associated with increased CYP2C19
enzyme activity. Subsequently, the* 17 variant has been demonstrated to decrease both …

The objective of this study was to determine the impact of polymorphism of CYP3A subfamily
isoenzymes (allelic variants of CYP3A4* 22 and CYP3A5* 3) on the efficacy clopidogrel in …