Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel
DJ Angiolillo, A Fernandez-Ortiz… - … , and vascular biology, 2006 - Am Heart Assoc
Objectives—Metabolic activity of cytochrome P450 (CYP) 3A4 has been associated with
clopidogrel response variability. Because metabolic activity of CYP3A4 is genetically …
clopidogrel response variability. Because metabolic activity of CYP3A4 is genetically …
CYP3A4 and MDR1 alleles in a Portuguese population
Polymorphisms in cytochrome P450 CYP3A4 and multidrug resistance (MDR) 1 genes
coding for the important drugmetabolising CYP3A4 and the ATP-binding cassette (ABC) …
coding for the important drugmetabolising CYP3A4 and the ATP-binding cassette (ABC) …
Genetic variability of CYP2C9*2 and CYP2C9*3 in seven indigenous groups from Mexico
K Sánchez-Pozos, C Rivera-Santiago… - …, 2016 - Taylor & Francis
Aim: CYP2C9 is one of the major drug metabolizing enzymes, however, little is known about
polymorphisms in CYP2C9 gene and pharmacological implications in Mexican indigenous …
polymorphisms in CYP2C9 gene and pharmacological implications in Mexican indigenous …
[HTML][HTML] Association of ABCB1 gene polymorphisms and clopidogrel responsiveness in Iranian patients undergoing percutaneous coronary intervention
S Namazi, E Sahebi, N Azarpira… - Iranian Journal of …, 2020 - ncbi.nlm.nih.gov
Clopidogrel is an antiplatelet agent currently used for preventing stent thrombosis. Despite
certain clinical benefits of clopidogrel in patients undergoing percutaneous coronary …
certain clinical benefits of clopidogrel in patients undergoing percutaneous coronary …
[HTML][HTML] Analysis of CYP2C19 genetic polymorphism in a large ethnic Hakka population in southern China
Z Zhong, J Hou, B Li, Q Zhang, S Liu, C Li… - … Medical Journal of …, 2017 - ncbi.nlm.nih.gov
Background Cytochrome P450 (CYP) 2C19 is an enzyme involved in the bioactivation of
various important therapeutic drugs, from pro-drugs to an active inhibitor of platelet action …
various important therapeutic drugs, from pro-drugs to an active inhibitor of platelet action …
The association between CYP2C19* 2 gene polymorphisms and clopidogrel resistance in the Han population of North China with coronary atherosclerotic heart …
Q Zhao, H Liu - Heart, 2012 - heart.bmj.com
Objectives Due to the diversification of platelet function test and defined criteria applied in
previous studies, there is a big difference in the incidence of CR. Besides, it remains unclear …
previous studies, there is a big difference in the incidence of CR. Besides, it remains unclear …
[HTML][HTML] Prevalence of CYP2C9 and CYP2C19 variants and the impact on clopidogrel efficacy in patients having CYPC19* 2 variant
MP Mehta, ND Gajjar, RJ Patel, LP Joshi… - Indian journal of …, 2023 - journals.lww.com
OBJECTIVE: Human cytochrome p450 enzymes play an important role in the metabolism of
various substances. The CYP2C subfamily consists of various important drug-metabolizing …
various substances. The CYP2C subfamily consists of various important drug-metabolizing …
CYP2C19 and PON1 Polymorphisms Regulating clopidogrel Bioactivation in Chinese, Malay and Indian Subjects
Aim, materials & methods: We investigated the functional significance of CYP2C19* 2,* 3,*
17 and PON1 Q192R SNPs in 89 consecutive Asian patients on clopidogrel treatment and …
17 and PON1 Q192R SNPs in 89 consecutive Asian patients on clopidogrel treatment and …
Gene polymorphism of cytochrome P450 2C19* 2 and clopidogrel resistance reflected by platelet function assays: a meta-analysis
X Hou, J Shi, H Sun - European journal of clinical pharmacology, 2014 - Springer
Background The relationship between CYP2C19* 2 gene polymorphism and clopidogrel
resistance reflected by platelet function assays has been studied extensively in the past …
resistance reflected by platelet function assays has been studied extensively in the past …
Prevalence of pharmacogenomic variants affecting the efficacy of clopidogrel therapy in the Hispanic Community Health Study/Study of Latinos cohort
Purpose: Although clopidogrel is the most widely used oral P2Y12 receptor antagonist, up to
10% of acute coronary syndrome patients treated with clopidogrel will experience a …
10% of acute coronary syndrome patients treated with clopidogrel will experience a …