OBJECTIVE: Human cytochrome p450 enzymes play an important role in the metabolism of
various substances. The CYP2C subfamily consists of various important drug-metabolizing …

Background The relationship between CYP2C19* 2 gene polymorphism and clopidogrel
resistance reflected by platelet function assays has been studied extensively in the past …

Background: Clinically relevant polymorphisms often demonstrate population-specific allele
frequencies. Central and South America remain largely uncategorized in the context of …

Background: Differences in genes encoding enzymes involved in the biotransformation of a
large number of compounds, such as CYP2D6, are related to inter-individual and inter …

Several polymorphisms in the CYP1A1 locus have been identified and their genotypes
appear to exhibit population frequencies that depend on ethnicity. We studied two CYP1A1 …

Clopidogrel decreases the morbidity and mortality associated with several cardiovascular
diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol …

Background The prevalence of variant alleles of the CYP2C19 gene has been determined
for most population groups, but not Native Americans. Furthermore, the overall effectiveness …

Aims: The aim of the study was to determine the association of single nucleotide
polymorphisms (SNPs) in selected cytochrome P (CYP) genes with plasma concentrations …

Background The antiplatelet activity of clopidogrel is variable among patients suffering from
ischemic heart disease. Variation in the cytochrome P450 2C19 (CYP2C19) gene coding for …

Aim: Polymorphisms in CYP2D6 impact the interindividual and interethnic variability of drug
efficiency; therefore, we determined the CYP2D6 allele distribution in eight Amerindian …