Genetic causes of clopidogrel nonresponsiveness: which ones really count?
KM Momary, MP Dorsch… - … : The Journal of Human …, 2010 - Wiley Online Library
Clopidogrel decreases the morbidity and mortality associated with several cardiovascular
diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol …
diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol …
[HTML][HTML] Genetic polymorphisms of CYP2C19 influences the response to clopidogrel in ischemic heart disease patients in the South Indian Tamilian population
K Subraja, SA Dkhar, R Priyadharsini… - European journal of …, 2013 - Springer
Background The antiplatelet activity of clopidogrel is variable among patients suffering from
ischemic heart disease. Variation in the cytochrome P450 2C19 (CYP2C19) gene coding for …
ischemic heart disease. Variation in the cytochrome P450 2C19 (CYP2C19) gene coding for …
[引用][C] Cytochrome p-450 polymorphisms and response to clopidogrel
AJ Marian - Current atherosclerosis reports, 2009 - Springer
Aims: The aim of the study was to determine the association of single nucleotide
polymorphisms (SNPs) in selected cytochrome P (CYP) genes with plasma concentrations …
polymorphisms (SNPs) in selected cytochrome P (CYP) genes with plasma concentrations …
CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico
BP Lazalde-Ramos, ML Martínez-Fierro… - …, 2014 - Taylor & Francis
Aim: Polymorphisms in CYP2D6 impact the interindividual and interethnic variability of drug
efficiency; therefore, we determined the CYP2D6 allele distribution in eight Amerindian …
efficiency; therefore, we determined the CYP2D6 allele distribution in eight Amerindian …
High Frequency of CYP1A* 2C Allele in Brazilian Populations
PA Gaspar, K Kvitko, LG Papadopolis, MH Hutz… - Human …, 2002 - muse.jhu.edu
The genetic variability of the CYP1A1 I462V polymorphism (CYP1A1* 2C) was investigated
in four Brazilian populations: three groups of African descent and one group of European …
in four Brazilian populations: three groups of African descent and one group of European …
[PDF][PDF] Polymorphisms of cytochrome P450 are potential candidates that could potentially help clinicians on the treatment of cardiovascular diseases among Asian …
LH Daniel - Indian Heart J, 2017 - cyberleninka.org
There are significant ethnic differences in the metabolism of some drugs that can be
explained by cytochrome P450 polymorphisms and, in particular, the CYP2D6 isozyme. In …
explained by cytochrome P450 polymorphisms and, in particular, the CYP2D6 isozyme. In …
Efffect of the ABCC3 –211C/T polymorphism on clopidogrel responsiveness in patients with percutaneous coronary intervention
JJ Zou, HW Fan, SL Chen, J Tan… - Clinical and …, 2013 - Wiley Online Library
Summary Multidrug resistance protein 3 (MPR3), encoded by the ATP‐binding cassette,
subfamily C (CFTR/MRP), member 3 (ABCC 3) gene, functions as an important drug efflux …
subfamily C (CFTR/MRP), member 3 (ABCC 3) gene, functions as an important drug efflux …
[HTML][HTML] Genetic determinants of response to clopidogrel and cardiovascular events
T Simon, C Verstuyft, M Mary-Krause… - New England journal …, 2009 - Mass Medical Soc
Background Pharmacogenetic determinants of the response of patients to clopidogrel
contribute to variability in the biologic antiplatelet activity of the drug. The effect of these …
contribute to variability in the biologic antiplatelet activity of the drug. The effect of these …
Allele frequency distribution of CYP2C19* 2 allelic variants associated with clopidogrel resistance in cardiac patients
KU Rehman, T Akhtar… - Experimental and …, 2015 - spandidos-publications.com
Drug resistance is a phenomenon that has become a critical issue in medical practice. Such
is the case in the response to clopidogrel treatment, which is variable inter‑individually and …
is the case in the response to clopidogrel treatment, which is variable inter‑individually and …
Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population
F de Andrés, C Altamirano-Tinoco… - The …, 2021 - nature.com
Interethnic variability in the drug-metabolizing capacity of CYP450 enzymes may lead to
discrepancies in the relationship between genotypes and phenotypes worldwide. The …
discrepancies in the relationship between genotypes and phenotypes worldwide. The …