Pannexins constitute a family of proteins exhibiting predominantly hemichannel activity.
Pannexin channels have been suggested to participate in a wide spectrum of biological …

Pannexin (Panx) 1 is a widely expressed protein that shares structural, but not amino acid,
homology with gap junction proteins, the connexins. Panx1 does not form gap junctions in …

Pannexins (Panx) are proteins with a similar membrane topology to connexins, the integral
membrane protein of gap junctions. Panx1 channels are generally of major importance in a …

The pannexin family of mammalian proteins, composed of Panx1, Panx2, and Panx3, has
been postulated to be a new class of single-membrane channels with functional similarities …

The mammalian pannexin family of channel‐forming proteins consisting of Panx1, Panx2,
and Panx3 has received considerable attention in the last 10 years given their newly …

Pannexins form high-conductance ion channels in the membranes of many vertebrate cells.
Functionally, they have been associated with multiple functional pathways like the …

Pannexins are newly discovered channel proteins expressed in many different tissues and
abundantly in the vertebrate central nervous system. Based on membrane topology, folding …

Pannexins are homologous to innexins, the invertebrate gap junction family. However,
mammalian pannexin1 does not form canonical gap junctions, instead forming hexameric …

Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and
represents a pathway for the release of cytosolic ATP. Several structurally similar connexin …