Role of n-3 fatty acids in muscle loss and myosteatosis

JB Ewaschuk, A Almasud… - … Physiology, Nutrition, and …, 2014 - cdnsciencepub.com
Image-based methods such as computed tomography for assessing body composition
enables quantification of muscle mass and muscle density and reveals that low muscle …

Targeting the myostatin signaling pathway to treat muscle wasting diseases

HQ Han, WE Mitch - Current opinion in supportive and palliative …, 2011 - journals.lww.com
Muscle wasting increases the risks of morbidity and mortality. But, the reliability of estimates
of the degree of muscle wasting is controversial as are definitions of terms like cachexia …

The vicious cycle of myostatin signaling in sarcopenic obesity: myostatin role in skeletal muscle growth, insulin signaling and implications for clinical trials

LA Consitt, BC Clark - The Journal of frailty & aging, 2018 - Springer
The age-related loss of skeletal muscle (sarcopenia) is a major health concern as it is
associated with physical disability, metabolic impairments, and increased mortality. The …

AI-based CT body composition identifies myosteatosis as key mortality predictor in asymptomatic adults

M Nachit, Y Horsmans, RM Summers, IA Leclercq… - Radiology, 2023 - pubs.rsna.org
Background Body composition data have been limited to adults with disease or older age.
The prognostic impact in otherwise asymptomatic adults is unclear. Purpose To use artificial …

Ectopic lipid accumulation and reduced glucose tolerance in elderly adults are accompanied by altered skeletal muscle mitochondrial activity

DL Johannsen, KE Conley, S Bajpeyi… - The Journal of …, 2012 - academic.oup.com
Context: Aging is associated with insulin resistance and unfavorable changes in body
composition including increased fat accumulation, particularly in visceral and ectopic …

Obesity, metabolic syndrome, and musculoskeletal disease: common inflammatory pathways suggest a central role for loss of muscle integrity

KH Collins, W Herzog, GZ MacDonald… - Frontiers in …, 2018 - frontiersin.org
Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …

Measurement of skeletal muscle: laboratory and epidemiological methods

WJ Evans, SB Heymsfield, D Gallagher… - The Journals of …, 1995 - academic.oup.com
Despite skeletal muscle's central role in the pathogenesis of sarcopenia, measurement
methods remain underinvestigated and inadequately validated. Our review indicates that …

Assessing skeletal muscle mass: historical overview and state of the art

SB Heymsfield, M Adamek, MC Gonzalez, G Jia… - Journal of cachexia …, 2014 - Springer
Background Even though skeletal muscle (SM) is the largest body compartment in most
adults and a key phenotypic marker of sarcopenia and cachexia, SM mass was until recently …

Adipose tissue quality in aging: how structural and functional aspects of adipose tissue impact skeletal muscle quality

FG De Carvalho, JN Justice, EC Freitas, EE Kershaw… - Nutrients, 2019 - mdpi.com
The interplay between adipose tissue and skeletal muscle and the impact on mobility and
aging remain enigmatic. The progressive decline in mobility promoted by aging has been …

Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men

A Granic, K Suetterlin, T Shavlakadze… - Clinical …, 2023 - portlandpress.com
Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …