Muscle wasting in myotonic dystrophies: a model of premature aging
AJ Mateos-Aierdi, M Goicoechea, A Aiastui… - Frontiers in aging …, 2015 - frontiersin.org
Myotonic dystrophy type 1 (DM1 or Steinert's disease) and type 2 (DM2) are multisystem
disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the …
disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the …
The relationships between sarcopenic skeletal muscle loss during ageing and macronutrient metabolism, obesity and onset of diabetes
AA Welch, RPG Hayhoe, D Cameron - Proceedings of the Nutrition …, 2020 - cambridge.org
Skeletal muscle is integral to the metabolism and utilisation of macronutrients; however,
substantial muscle loss and morphological changes occur with ageing. These are …
substantial muscle loss and morphological changes occur with ageing. These are …
The role of systemic inflammation in cancer‐associated muscle wasting and rationale for exercise as a therapeutic intervention
Progressive skeletal muscle wasting in cancer cachexia involves a process of dysregulated
protein synthesis and breakdown. This catabolism may be the result of mal‐nutrition, and an …
protein synthesis and breakdown. This catabolism may be the result of mal‐nutrition, and an …
Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults
G Distefano, RA Standley, X Zhang… - Journal of cachexia …, 2018 - Wiley Online Library
Background The concept of mitochondrial dysfunction in ageing muscle is highly
controversial. In addition, emerging evidence suggests that reduced muscle oxidative …
controversial. In addition, emerging evidence suggests that reduced muscle oxidative …
[PDF][PDF] Linking age-related changes in skeletal muscle mass and composition with metabolism and disease
Skeletal muscle (SM) plays a central role in many biological functions, such as movement
and metabolism, and alterations in SM mass and composition can have a marked influence …
and metabolism, and alterations in SM mass and composition can have a marked influence …
Skeletal muscle atrophy: From mechanisms to treatments
L Yin, N Li, W Jia, N Wang, M Liang, X Yang… - Pharmacological …, 2021 - Elsevier
Skeletal muscle is a crucial tissue for movement, gestural assistance, metabolic
homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight …
homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight …
[HTML][HTML] Skeletal muscle fat infiltration: impact of age, inactivity, and exercise
Fat infiltration within the fascial envelope of the thigh or intermuscular adispose tissue
(IMAT), has been shown to be associated with both adverse metabolic and mobility …
(IMAT), has been shown to be associated with both adverse metabolic and mobility …
High fat with high sucrose diet leads to obesity and induces myodegeneration
Skeletal muscle utilizes both free fatty acids (FFAs) and glucose that circulate in the blood
stream. When blood glucose levels acutely increase, insulin stimulates muscle glucose …
stream. When blood glucose levels acutely increase, insulin stimulates muscle glucose …
[HTML][HTML] Impact of skeletal muscle mass on metabolic health
G Kim, JH Kim - Endocrinology and Metabolism, 2020 - synapse.koreamed.org
Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory
proteins, referred to as myokines, mediate interactions between skeletal muscle mass and …
proteins, referred to as myokines, mediate interactions between skeletal muscle mass and …
Age-associated differences in triceps surae muscle composition and strength–an MRI-based cross-sectional comparison of contractile, adipose and connective tissue
Background In human skeletal muscles, the aging process causes a decrease of contractile
and a concomitant increase of intramuscular adipose (IMAT) and connective (IMCT) tissues …
and a concomitant increase of intramuscular adipose (IMAT) and connective (IMCT) tissues …