Treating cancer cachexia to treat cancer

SJ Lee, DJ Glass - Skeletal muscle, 2011 - Springer
Skeletal muscle wasting is a major component of cachectic states found in a variety of
disease settings, including cancer. As increasing caloric intake often provides little benefit in …

Pathophysiological mechanisms explaining the association between low skeletal muscle mass and cognitive function

SJ Oudbier, J Goh, SMLM Looijaard… - The Journals of …, 2022 - academic.oup.com
Low skeletal muscle mass is associated with cognitive impairment and dementia in older
adults. This review describes the possible underlying pathophysiological mechanisms …

Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia

C Harper, V Gopalan, J Goh - Journal of translational medicine, 2021 - Springer
Skeletal muscle aging is associated with a decline in motor function and loss of muscle
mass-a condition known as sarcopenia. The underlying mechanisms that drive this …

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

E Marzetti, R Calvani, M Cesari, TW Buford… - The international journal …, 2013 - Elsevier
Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …

The influence of skeletal muscle on systemic aging and lifespan

F Demontis, R Piccirillo, AL Goldberg, N Perrimon - Aging cell, 2013 - Wiley Online Library
Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the
development of several age‐related diseases such as metabolic syndrome, cancer, A …

[HTML][HTML] Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders

RC Smith, BK Lin - Current opinion in supportive and palliative …, 2013 - journals.lww.com
Myostatin inhibitors as therapies for muscle wasting associa... : Current Opinion in Supportive
and Palliative Care Myostatin inhibitors as therapies for muscle wasting associated with cancer …

Mitochondrial dysfunction is a common denominator linking skeletal muscle wasting due to disease, aging, and prolonged inactivity

HW Hyatt, SK Powers - Antioxidants, 2021 - mdpi.com
Skeletal muscle is the most abundant tissue in the body and is required for numerous vital
functions, including breathing and locomotion. Notably, deterioration of skeletal muscle …

Muscle–organ crosstalk: the emerging roles of myokines

MCK Severinsen, BK Pedersen - Endocrine reviews, 2020 - academic.oup.com
Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training

NT Broskey, C Greggio, A Boss… - The Journal of …, 2014 - academic.oup.com
Context: Sarcopenia is thought to be associated with mitochondrial (Mito) loss. It is unclear
whether the decrease in Mito content is consequent to aging per se or to decreased physical …

Understanding sex differences in the regulation of cancer-induced muscle wasting

RN Montalvo, BR Counts… - Current opinion in …, 2018 - journals.lww.com
Understanding sex differences in the regulation of cancer-in... : Current Opinion in Supportive
and Palliative Care Understanding sex differences in the regulation of cancer-induced muscle …