Treating cancer cachexia to treat cancer
Skeletal muscle wasting is a major component of cachectic states found in a variety of
disease settings, including cancer. As increasing caloric intake often provides little benefit in …
disease settings, including cancer. As increasing caloric intake often provides little benefit in …
Pathophysiological mechanisms explaining the association between low skeletal muscle mass and cognitive function
SJ Oudbier, J Goh, SMLM Looijaard… - The Journals of …, 2022 - academic.oup.com
Low skeletal muscle mass is associated with cognitive impairment and dementia in older
adults. This review describes the possible underlying pathophysiological mechanisms …
adults. This review describes the possible underlying pathophysiological mechanisms …
Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia
C Harper, V Gopalan, J Goh - Journal of translational medicine, 2021 - Springer
Skeletal muscle aging is associated with a decline in motor function and loss of muscle
mass-a condition known as sarcopenia. The underlying mechanisms that drive this …
mass-a condition known as sarcopenia. The underlying mechanisms that drive this …
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …
on individuals and society. The development of preventive and therapeutic strategies …
The influence of skeletal muscle on systemic aging and lifespan
F Demontis, R Piccirillo, AL Goldberg, N Perrimon - Aging cell, 2013 - Wiley Online Library
Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the
development of several age‐related diseases such as metabolic syndrome, cancer, A …
development of several age‐related diseases such as metabolic syndrome, cancer, A …
[HTML][HTML] Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders
RC Smith, BK Lin - Current opinion in supportive and palliative …, 2013 - journals.lww.com
Myostatin inhibitors as therapies for muscle wasting associa... : Current Opinion in Supportive
and Palliative Care Myostatin inhibitors as therapies for muscle wasting associated with cancer …
and Palliative Care Myostatin inhibitors as therapies for muscle wasting associated with cancer …
Mitochondrial dysfunction is a common denominator linking skeletal muscle wasting due to disease, aging, and prolonged inactivity
Skeletal muscle is the most abundant tissue in the body and is required for numerous vital
functions, including breathing and locomotion. Notably, deterioration of skeletal muscle …
functions, including breathing and locomotion. Notably, deterioration of skeletal muscle …
Muscle–organ crosstalk: the emerging roles of myokines
MCK Severinsen, BK Pedersen - Endocrine reviews, 2020 - academic.oup.com
Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …
Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training
NT Broskey, C Greggio, A Boss… - The Journal of …, 2014 - academic.oup.com
Context: Sarcopenia is thought to be associated with mitochondrial (Mito) loss. It is unclear
whether the decrease in Mito content is consequent to aging per se or to decreased physical …
whether the decrease in Mito content is consequent to aging per se or to decreased physical …
Understanding sex differences in the regulation of cancer-induced muscle wasting
RN Montalvo, BR Counts… - Current opinion in …, 2018 - journals.lww.com
Understanding sex differences in the regulation of cancer-in... : Current Opinion in Supportive
and Palliative Care Understanding sex differences in the regulation of cancer-induced muscle …
and Palliative Care Understanding sex differences in the regulation of cancer-induced muscle …