V-HeFT, the first mortality trial in patients with heart failure, has provided important insights
regarding trial design, including patient selection and efficacy criteria. Planning of V-HeFT II …

Summary The Veterans Affairs Vasodilator-Heart Failure Trials (V-HeFT I and II) provided
information about heart failure treated with conventional therapy, and evaluated the long …

Old Dog, New Endothelial Tricks have to take you back in history a little bit. In 1973, we
wrote an article in Circulation in which we hypothesized a role for the peripheral circulation …

The Veterans Administration Cooperative Study on Vasodilator Therapy of Heart Failure was
designed to determine whether vasodilator drugs could alter the survival of patients with …

Background The effects of hydralazine plus isosorbide dinitrate were compared with those of
enalapril in 804 men receiving digoxin and diuretic therapy for chronic congestive heart …

Abstract Background and Methods. To define better the efficacy of vasodilator therapy in the
treatment of chronic congestive heart failure, we compared the effects of hydralazine and …

During the past 25 years, considerable progress has been made in our understanding of the
pathophysiological mechanisms for the development and progression of the heart failure …

The treatment of congestive heart failure has evolved considerably over the past 15 years.
State of the art therapy utilizes a combination of three classes of medications: digitalis …

We examined existing evidence concerning the relative efficacy of various vasodilator
agents in chronic congestive heart failure. Only randomized placebo-controlled trials with …

PARADIGM-HF trial in the Journal (pages 993–1004) we may be entering a new era of
treatment for heart failure with reduced ejection fraction. To provide a historical perspective …