Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

REW Hancock, HG Sahl - Nature biotechnology, 2006 - nature.com
Short cationic amphiphilic peptides with antimicrobial and/or immunomodulatory activities
are present in virtually every life form, as an important component of (innate) immune …

Host defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections

A Nijnik, REW Hancock - Emerging health threats journal, 2009 - Taylor & Francis
The rapidly increasing incidence of multidrug-resistant infections and the alarmingly low rate
of discovery of conventional antibiotics create an urgent need for alternative strategies to …

Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Antimicrobial peptides: therapeutic potential

L Zhang, TJ Falla - Expert opinion on pharmacotherapy, 2006 - Taylor & Francis
A significant component of the innate immune system of a wide variety of animals and plants
is arbitrated by cationic host defence peptides. In man, these peptides, in addition to …

Cationic host defense (antimicrobial) peptides

KL Brown, REW Hancock - Current opinion in immunology, 2006 - Elsevier
Members of the cationic host defense (antimicrobial) peptide family are widely distributed in
nature, existing in organisms from insects to plants to mammals and non-mammalian …

[HTML][HTML] Aggregation and its influence on the immunomodulatory activity of synthetic innate defense regulator peptides

EF Haney, BC Wu, K Lee, AL Hilchie… - Cell Chemical …, 2017 - cell.com
There is increasing interest in developing cationic host defense peptides (HDPs) and their
synthetic derivatives as antimicrobial, immunomodulatory, and anti-biofilm agents. These …

[HTML][HTML] Defense peptides: recent developments

M Cytryńska, A Zdybicka-Barabas - Biomolecular concepts, 2015 - degruyter.com
Defense peptides are small amphipathic molecules that exhibit antimicrobial, antitumor,
antiviral, and immunomodulatory properties. This review summarizes current knowledge on …

Host defense peptides: front-line immunomodulators

SC Mansour, OM Pena, REW Hancock - Trends in immunology, 2014 - cell.com
Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now
widely recognized for their multifunctional roles in both the innate and adaptive immune …

Host defense peptides as immunomodulators: The other side of the coin

EM Martell, M Gonzalez-Garcia, L Ständker… - Peptides, 2021 - Elsevier
Host defense peptides (HDPs) exhibit a broad range of antimicrobial and
immunomodulatory activities. In this sense, both functions are like different sides of the same …

Design of host defence peptides for antimicrobial and immunity enhancing activities

JB McPhee, MG Scott… - Combinatorial chemistry & …, 2005 - ingentaconnect.com
Host defense peptides are a vital component of the innate immune systems of humans, other
mammals, amphibians, and arthropods. The related cationic antimicrobial peptides are also …