Adenosine is an endogenous nucleoside, released into the extracellular space in response
to metabolic stress and cell damage and critically involved in the maintenance of tissue …

Adenosine is increasingly recognized as a key mediator of the immune response. Signals
delivered by extracellular adenosine are detected and transduced by G-protein-coupled cell …

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …

Adenosine is an endogenous purine nucleoside that, following its release into the
extracellular space, binds to specific adenosine receptors expressed on the cell surface …

Extracellular adenosine is produced in a coordinated manner from cells following cellular
challenge or tissue injury. Once produced, it serves as an autocrine-and paracrine-signaling …

Although inflammatory and immunological reactions protect the host from invasion by
microorganisms and eliminate debris at sites of tissue injury, they can also be responsible …

After a century of research, several lines of evidence now indicate that the ability of
adenosine to directly control inflammatory cells has a major impact on the functions of the …

Adenosine, an endogenous nucleoside that is ubiquitous in many mammalian cell types,
has been shown to regulate a number of physiological properties. The mechanism by which …

Adenosine can be described as a retaliatory metabolite, the production and release of which
is usually enhanced under adverse environmental conditions. Binding via specific receptors …

Since the late 1920s, the importance of the physiological role of adenosine triphosphate
(ATP) and its metabolites, mainly adenosine, has been clear. In 1970, strong evidence now …