Determining the effect of hypothalamic inflammatory signals on energy balance presents a
paradox. On the one hand, a large body of work has identified inflammatory signaling in the …

The control of energy homeostasis relies on robust neuronal circuits that regulate food
intake and energy expenditure. Although the physiology of these circuits is well understood …

Diet-induced obesity leads to devastating and common chronic diseases, fueling ongoing
interest in determining new mechanisms underlying both obesity and its consequences. It is …

The hypothalamus is one of the master regulators of various physiological processes,
including energy balance and nutrient metabolism. These regulatory functions are mediated …

Obesity is one of the worldwide prevalent disease caused by the imbalance between food
intake and energy expenditure. Over a 100 years of research demonstrate that …

The hypothalamus is a crucial organ for the maintenance of appropriate body fat storage.
Neurons in the hypothalamic arcuate nucleus (ARH) detect energy shortage or surplus via …

In experimental models, hypothalamic dysfunction is a key component of the
pathophysiology of diet-induced obesity. Early after the introduction of a high-fat diet …

Obesity and its comorbidities are long-standing, challenging global health problems. Lack of
exercise, overnutrition, and especially the consumption of fat-rich foods are some of the most …

Obesity and its associated metabolic and cardio-vascular disorders are among the most chal-
lenging health problems confronting developed countries. Not only is obesity remarkably …

Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in
peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the …