[HTML][HTML] The dynamic transcriptional cell atlas of testis development during human puberty
The human testis undergoes dramatic developmental and structural changes during
puberty, including proliferation and maturation of somatic niche cells, and the onset of …
puberty, including proliferation and maturation of somatic niche cells, and the onset of …
The adult human testis transcriptional cell atlas
Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …
[HTML][HTML] Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment
Human testis development in prenatal life involves complex changes in germline and
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …
A comprehensive roadmap of murine spermatogenesis defined by single-cell RNA-seq
Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
Research resource: the dynamic transcriptional profile of sertoli cells during the progression of spermatogenesis
Sertoli cells (SCs), the only somatic cells within seminiferous tubules, associate intimately
with developing germ cells. They not only provide physical and nutritional support but also …
with developing germ cells. They not only provide physical and nutritional support but also …
The neonatal and adult human testis defined at the single-cell level
Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing
Spermatogenesis is the process by which male gametes are formed from a self-renewing
population of spermatogonial stem cells (SSCs) residing in the testis. SSCs represent less …
population of spermatogonial stem cells (SSCs) residing in the testis. SSCs represent less …
Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis
D Rebourcet, PJ O'Shaughnessy, JL Pitetti… - …, 2014 - journals.biologists.com
Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main
regulators of spermatogenesis in the adult testis; however, their role during the intervening …
regulators of spermatogenesis in the adult testis; however, their role during the intervening …
[HTML][HTML] The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids
Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
Transcription and imprinting dynamics in developing postnatal male germline stem cells
Postnatal spermatogonial stem cells (SSCs) progress through proliferative and
developmental stages to populate the testicular niche prior to productive spermatogenesis …
developmental stages to populate the testicular niche prior to productive spermatogenesis …