Superantigens are a class of highly potent immuno-stimulatory molecules produced by
Staphylococcus aureus and Streptococcus pyogenes. These toxins possess the unique …

Background: Staphylococcus aureus enterotoxin C2 (SEC2) belongs to a family of proteins,
termed 'superantigens', that form complexes with class II MHC molecules enabling them to …

THE αβ T-cell receptors (TCRs) react with complex ligands composed of peptides bound to
major histocompatibility complex (MHC) proteins. In the absence of foreign antigens the …

Superantigens are a class of immunostimulatory molecules produced by bacterla and
viruses. Their potent immune effects are due to their unique ability to bind to the major …

Bacterial superantigens (SAgs) are potent activators of T lymphocytes and play a
pathophysiological role in Gram‐positive septic shock and food poisoning. To characterize …

Class I major histocompatibility complex (MHC) molecules function in the recognition of
antigens by cytotoxic T lymphocytes (CTL) 1, 2. Although this biological role is firmly …

Abstract A complex between HLA-DR3 and a fragment of invariant chain called CLIP was
isolated from a human cell line defective in antigen presentation and its X-ray crystal …

SUPERANTIGENS1–4 bind class II major histocompatibility pro-teins5, 6 and stimulate
powerful proliferative responses of T lymphocytes bearing particular V β sequences as part …

The class-I and class-II molecules encoded by the major histocompatibility complex (MHC)
are homologous proteins which allow cytotoxic and helper T cells to recognize foreign …

We have used multiple-amino acid replacement mutagenesis to examine the roles of the
TCR homologues of Ig complementarity-determining regions (CDR) and framework …