Under normoxic conditions the hypoxia-inducible factor-1α (HIF-1α) protein is targeted for
degradation by the von Hippel-Lindau (pVHL) tumor suppressor protein acting as an E3 …

In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the
ubiquitin‐proteasome pathway, and activation of HIF‐1α to a functional form requires protein …

Hypoxia-inducible factor-1α (HIF-1α) 1 is a global transcriptional regulator of the hypoxic
response. Under normoxic conditions, HIF-1α is recognized by the von Hippel-Lindau tumor …

The hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that mediates adaptive
cellular responses to decreased oxygen availability (hypoxia). At normoxia, HIF-1α is …

The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in
cellular responses to oxygen availability, being required for the oxygen-dependent …

Stabilization of the hypoxia-inducible factor-1 (HIF-1) protein is essential for its role as a
regulator of gene expression under low oxygen conditions. Here, employing a novel …

Abstract Hypoxia-inducible factor (HIF)-1α is a transcription factor that plays a critical role in
regulating genes involved in erythropoiesis and angiogenesis. Recent evidence indicates …

Oxygen‐dependent proteolytic destruction of hypoxia‐inducible factor‐α (HIF‐α) subunits
plays a central role in regulating transcriptional responses to hypoxia. Recent studies have …

Hypoxia–inducible factor (HIF) remains the central focus of oxygen sensing during hypoxia.
HIF is a heterodimeric transcription factor consisting of an oxygen-regulated alpha-and a …

Adaptive responses to hypoxia are essential for the survival of all organisms. Under hypoxic
conditions, the transcription of a large group of genes relevant for oxygen homeostasis is …