Hypoxia-inducible factors (HIFs) are heterodimeric oxygen-sensitive basic helix-loop-helix
transcription factors that play central roles in cellular adaptation to low oxygen environments …

The transcriptional activator complex HIF-1 plays a key role in the long term adaptation of
cells and tissues to their hypoxic microenvironment by stimulating the expression of genes …

Most of the genes induced by hypoxia are regulated by a family of transcription factors
termed hypoxia-inducible factors (HIF). Under normoxic conditions, HIFα proteins are very …

Abstract The von Hippel-Lindau (VHL) tumour suppressor gene encodes a substrate-
specifying component of an E3 ubiquitin ligase that targets hypoxia-inducible factor (HIF) α …

Recently, work on the mechanism of action of the von Hippel–Lindau tumour suppressor
protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights …

Functional inactivation of the von Hippel-Lindau (VHL) tumor suppressor protein is the
cause of familial VHL disease and sporadic kidney cancer. The VHL gene product (pVHL) is …

Abstract Hypoxia-inducible factor-1α (HIF-1α) induction and associated transcription were
investigated during high cell density, focusing on the negative regulator of HIF-1α …

In the present study, the role of the C-terminal α-helical domain (amino acid (aa) 195–208)
of the von Hippel–Lindau (VHL) tumour suppressor was investigated. Deletions of the VHL …

Hypoxia-inducible factor 1 complex (HIF-1) plays a pivotal role in oxygen homeostasis and
adaptation to hypoxia. Its function is controlled by both the protein stability and the …

Hypoxia-inducible factor (HIF) mediates a widespread transcriptional response to hypoxia
through binding to cis-acting DNA sequences termed hypoxia response elements (HREs) …