Mammalian cells sense changes in oxygen and transduce that information into adaptive
changes in gene expression using a conserved pathway that converges on the …

Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the
regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-α …

The hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes (PHDs) regulate the
stability of HIF protein by post-translational hydroxylation of two conserved prolyl residues in …

Abstract von Hippel–Lindau (VHL) disease is a hereditary cancer syndrome that is
characterized by the development of multiple vascular tumors and is caused by inactivation …

HIF-1α (hypoxia-inducible factor 1α) is a basic-helix-loop-helix PAS (Per/Arnt/Sim)
transcription factor that, under hypoxic conditions, dimerizes with a partner factor, the basic …

The product of the von Hippel-Lindau (VHL) tumor suppressor gene, pVHL, functions as a
ubiquitin-protein isopeptide ligase in regulating HIF-1 protein turnover, thus accounting for …

The tumor suppressor function of the von Hippel-Lindau protein (pVHL) has previously been
linked to its role in regulating hypoxia-inducible factor levels. However, VHL gene mutations …

The hypoxia‐inducible factor (HIF) is a heterodimeric basic helix‐loop‐helix (bHLH)
transcription factor that controls the mammalian cellular transcriptional response to low …

There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible
factors (HIFs), the master transcriptional regulators that respond to changes in intracellular …

In the presence of oxygen and iron, hypoxia-inducible factor (HIF-1α) is rapidly degraded via
the prolyl hydroxylases (PHD)/VHL pathways. Given striking similarities between p53 and …