In animals, the post-translational hydroxylation of hypoxia inducible factor (HIF) is a central
mechanism for regulating gene expression in an oxygen-dependent manner. The …

The hypoxia-inducible factor 1 transcriptional activator complex (HIF-1) is involved in the
activation of the erythropoietin and several other hypoxia-responsive genes. The HIF-1 …

The product of the von Hippel–Lindau gene, pVHL, targets the α subunits of the
heterodimeric transcription factor hypoxia-inducible factor (HIF) for polyubiquitination in the …

HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular
adaptation to changes in oxygen availability. In the presence of oxygen, HIF is targeted for …

The hypoxia-inducible factor-1 (HIF-1) is the master regulator of the cellular response to
hypoxia and its expression levels are tightly controlled through synthesis and degradation. It …

Abstract The von Hippel‐Lindau tumor suppressor protein (pVHL) has an essential role in
the regulation of the hypoxia response pathway in animal cells. Under normoxic conditions …

Matching oxygen consumption and supply represents a fundamental challenge to
multicellular organisms. HIF-1 is a transcription complex which is emerging as a key …

An important regulator involved in oxygen-dependent gene expression is the transcription
factor HIF (hypoxia-inducible factor), which is composed of an oxygen-sensitive α-subunit …

The hypoxia-inducible factors HIF-1α and HIF-2α are structurally similar as regards their
DNA-binding and dimerization domains, but differ in their transactivation domains and, as is …

Over the past decade major advances have been made in our understanding of the
molecular machinery that mammalian cells use to sense and to adapt to a low-oxygen …