Hypoxia-inducible factor 1α (HIF-1α) is rapidly degraded by the ubiquitin-proteasome
pathway under normoxic conditions. Ubiquitination of HIF-1α is mediated by interaction with …

Hypoxia inducible factor (HIF) is regulated by dual pathways involving oxygen-dependent
prolyl and asparaginyl hydroxylation of its α-subunits. Prolyl hydroxylation at two sites within …

Regulation of the growth and metabolism of large organisms is tightly constrained by the
need for precise oxygen homeostasis. Work on control of the haematopoietic growth factor …

The transcription factor hypoxia-inducible factor (HIF)-1 is an important mediator of hypoxic
adaptation of tumor cells and controls several genes that have been implicated in tumor …

Abstract Hypoxia-inducible factor-1α (HIF-1α) is a master transcription factor that is critical for
the regulation of a variety of cellular functions. HIF-1α is rapidly degraded under normoxic …

ABSTRACT Hypoxia‐inducible factor (HIF)‐1α, a master regulator of oxygen homeostasis,
regulates genes crucial for cell growth and survival. In normoxia, HIF‐1α is constantly …

The function of the hypoxia-inducible factor-1 (HIF-1), the key transcription factor involved in
cellular adaptation to hypoxia, is restricted to low oxygen tension (pO2). As such, this …

Hypoxia-inducible factor 1 (HIF-1) is controlled through stability regulation of its alpha
subunit, which is expressed under hypoxia but degraded under normoxia. Degradation of …

The mechanism by which hypoxia induces gene transcription involves the inhibition of
hypoxia-inducible factor (HIF)-1α prolyl hydroxylase activity, which prevents von Hippel …

HIF-1α is a normally labile proangiogenic transcription factor that is stabilized and activated
in hypoxia. Although the von Hippel Lindau (VHL) gene product, the ubiquitin ligase …