Skeletal muscle is an adaptive tissue that possesses an innate ability to fully regenerate
from a damaging stimulus. Type 1 diabetes mellitus (T1DM) elicits a pathophysiological …

Sphingosine 1-phosphate (S1P) is a bioactive lipid involved in the regulation of biological
processes such as proliferation, differentiation, motility, and survival. Here we review the role …

Type 1 diabetes mellitus (T1DM) impairs regenerative capacity of skeletal muscle, one of
several aspects of diabetic myopathy. It was hypothesized that accumulation of lipid species …

Sphingolipids were discovered more than a century ago and were simply considered as a
class of cell membrane lipids for a long time. However, after the discovery of several …

Background: Features of type 1 diabetes mellitus (T1DM) include impaired skeletal muscle
regenerative capacity and accumulation of muscle lipids; however, the influence of lipids …

Studies performed in the last fifteen years have clearly established that the bioactive
sphingolipid sphingosine 1-phosphate (S1P) affects various different biological properties of …

Background Presently, there is no effective treatment for the lethal muscle wasting disease
Duchenne muscular dystrophy (DMD). Here we show that increased sphingosine-1 …

Sphingosine 1-phosphate (S1P) is a bioactive lipid known to control cell growth that was
recently shown to act as a trophic factor for skeletal muscle, reducing the progress of …

Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and
promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads …

Abstract Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid regulator of numerous
important physiological and pathological processes in mammalian and nonmammalian …