COX-2 inhibition and colorectal cancer
CH Koehne, RN Dubois - Seminars in oncology, 2004 - Elsevier
Mortality in patients with advanced colorectal cancer (CRC) remains high. Epidemiologic
studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs …
studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs …
COX-2: a molecular target for colorectal cancer prevention
JR Brown, RN DuBois - Journal of Clinical Oncology, 2005 - ascopubs.org
Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …
considerable attention due to its role in human cancers. Observational and randomized …
Targeting cyclooxygenase‐2 for prevention and therapy of colorectal cancer
FA Sinicrope - … : Published in cooperation with the University of …, 2006 - Wiley Online Library
Abstract Cyclooxygenase‐2 (COX‐2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A …
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A …
COX-2 and colorectal cancer
A Ferrandez, S Prescott, RW Burt - Current pharmaceutical …, 2003 - ingentaconnect.com
Metabolites of arachidonic acid participate in normal growth responses and in aberrant
cellular growth and proliferation, including carcinogenesis. The key step in the conversion of …
cellular growth and proliferation, including carcinogenesis. The key step in the conversion of …
Celecoxib for the prevention of colorectal adenomatous polyps
N Arber, CJ Eagle, J Spicak, I Rácz… - … England Journal of …, 2006 - Mass Medical Soc
Background Overexpression of cyclooxygenase 2 (COX-2) has been associated with
colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition …
colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition …
Role of cyclooxygenase-2 in colorectal cancer
FA Sinicrope, S Gill - Cancer and Metastasis Reviews, 2004 - Springer
Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …
Cyclooxygenase 2: a molecular target for cancer prevention and treatment
K Subbaramaiah, AJ Dannenberg - Trends in pharmacological sciences, 2003 - cell.com
Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …
Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
RA Gupta, RN DuBois - Nature Reviews Cancer, 2001 - nature.com
Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …
COX-2 inhibition as a tool to treat and prevent colorectal cancer
JB Tuynman, MP Peppelenbosch, DJ Richel - Critical reviews in oncology …, 2004 - Elsevier
The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …
Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors
BS Reddy, CV Rao - Journal of environmental pathology …, 2002 - dl.begellhouse.com
During recent years, multidisciplinary studies in epidemiology and molecular biology, as
well as preclinical studies, have contributed much to our understanding of the etiology of …
well as preclinical studies, have contributed much to our understanding of the etiology of …