Mortality in patients with advanced colorectal cancer (CRC) remains high. Epidemiologic
studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs …

Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …

Abstract Cyclooxygenase‐2 (COX‐2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A …

Metabolites of arachidonic acid participate in normal growth responses and in aberrant
cellular growth and proliferation, including carcinogenesis. The key step in the conversion of …

Background Overexpression of cyclooxygenase 2 (COX-2) has been associated with
colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …

Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …

During recent years, multidisciplinary studies in epidemiology and molecular biology, as
well as preclinical studies, have contributed much to our understanding of the etiology of …