After introduction into the circulation most drugs are bound to the different blood constituents
(cells, proteins). Within the plasma proteins, serum albumin is undoubtedly the most …

Keyphrases 0 Binding, protein-various drugs to albumin and plasma proteins,
pharmacokinetics, drug displacement, and clinical significance, review 0 Protein binding …

Purpose. The purpose of this study was the classification and identification of drug binding
sites on albumins from several species in order to understand species differences of both …

Most drugs are bound to human serum albumin (HSA) via a few high affinity binding sites
and several sites of much lower affinity. There is now increasing evidence that the actual …

Recent work with approaches like recombinant mutants and X-ray crystallography has given
much new information about the ligand-binding properties of human serum albumin (HSA) …

Most drugs are carried from their sites of absorption to their sites of action and elimination by
the circulating blood. Some drugs are simply dissolved in serum water, but many others are …

Human serum albumin (HSA) possesses at least three sites or areas for high-affinity binding
of drugs. Of these sites, site I was investigated by series of ultrafiltration and equilibrium …

Human serum albumin (HSA) is the major plasma protein with vital functions acting as depot
and career for many endogenous (fatty acids, bilirubin, etc.) and exogenous substances …

This paper reports a variety of experimental observations which strongly support the
assumption that the warfarin binding site, or site I of human serum albumin, is better …

Background Human serum albumin acts as a reservoir and transport protein for endogenous
(eg fatty acids or bilirubin) and exogenous compounds (eg drugs or nutrients) in the blood …