Background Combination therapy employing multiple drugs has been shown to enhance the
efficacy of cancer treatment. Chlorambucil (Chl) and 6-mercaptopurine (6MP) are the first …

Herein, the clinically approved nitrogen mustard, chlorambucil (Chl), is covalently
embedded into a poly (N-(2-hydroxypropyl) methacrylamide, HPMA) vector via a …

In the latest several decades, we have witnessed the striking development of synthetic
polymers as drug carriers from the early issue as implant agents to update various nano …

Cancer is the second leading cause of death worldwide. It was estimated that 90% of cancer-
related deaths were attributable to the development of multi-drug resistance (MDR) during …

Mercaptopurine is a medication employed to treat autoimmune illnesses and cancer.
However, due to its poor solubility, quick metabolism, and possible side effects, it is not very …

Background Smart materials capable of responding to external stimuli are noteworthy
candidates in designing drug delivery systems. In many of the recent research, temperature …

Background Acute lymphoblastic leukemia (ALL) is the most common hematologic
malignancy in children. It requires a long and rigorous course of chemotherapy treatments. 6 …

Therapeutic strategies used to treat cancer are focused on cytotoxic drugs as the main form
of chemotherapy. Recently nanocarrier-based chemotherapy has been widely used to treat …

Recently, polymer drug conjugates (PDCs) have attracted considerable attention in the
treatment of cancer. In this work, a simple strategy has been developed to make PDCs of an …

Background It is of great significance to develop intelligent co-delivery systems for cancer
chemotherapy with improved therapeutic efficacy and few side-effects. Materials and …