Background Growing evidence has demonstrated that DNA methylation (DNAm) plays an
important role in Alzheimer's disease (AD) and that DNAm differences can be detected in the …

Introduction This study determined whether blood DNA methylation (DNAm) patterns
differentiate individuals with presymptomatic dementia compared to controls. Methods …

Background Identifying biomarkers associated with Alzheimer's disease (AD) progression
may enable patient enrichment and improve clinical trial designs. Epigenome-wide …

Alzheimer's disease (AD) is a common aging-related neurodegenerative illness. Recently,
many studies have tried to identify AD-or aging-related DNA methylation (DNAm) …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

Background Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease
impacting an estimated 44 million adults worldwide. The causal pathology of AD …

Alzheimer's disease (AD) is the most common cause of dementia with advancing age as its
strongest risk factor. AD neuropathologic change (ADNC) is known to be associated with …

Late-onset Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder
that likely involves epigenetic factors. To better understand the epigenetic state associated …

Background Sex is increasingly recognized as a significant factor contributing to the
biological and clinical heterogeneity in AD. There is also growing evidence for the prominent …

Dementia is a major public health issue with rising prevalence rates, but many individuals
remain undiagnosed. Accurate and timely diagnosis is key for the optimal targeting of …