Perivascular mesenchymal stem and progenitor cells (MSPCs) are critical for forming a
healthy hematopoietic stem cell (HSC) niche. However, the interactions and influence of …

Hematopoietic stem cells (HSCs) reside in specialized bone marrow (BM) niches regulated
by the sympathetic nervous system (SNS). Here, we have examined whether mononuclear …

Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically
remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) …

Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight
response was recognized decades ago, the crucial role of peripheral innervation in …

Hematopoietic stem and progenitor cells (HSPC), attracted by the chemokine CXCL12,
reside in specific niches in the bone marrow (BM). HSPC migration out of the BM is a critical …

Acute myeloid leukemia (AML) disrupts the generation of normal blood cells, predisposing
patients to hemorrhage, anemia, and infections. Differentiation and proliferation of residual …

Arterioles and sinusoids of the bone marrow (BM) are accompanied by stromal cells that
express nerve/glial antigen 2 (NG2) and leptin receptor (LepR), and constitute specialized …

The bone marrow microenvironment (BME) in acute myeloid leukemia (AML) consists of
various cell types that support the growth of AML cells and protect them from chemotherapy …

Bone marrow (BM) microenvironment contributes to the regulation of normal hematopoiesis
through a finely tuned balance of self-renewal and differentiation processes, cell–cell …

The sympathetic nervous system has been evolutionary selected to respond to stress and
activates haematopoietic stem cells via noradrenergic signals. However, the pathways …