Mitochondrial signaling and fertilization

J Van Blerkom, P Davis - Molecular human reproduction, 2007 - academic.oup.com
The magnitude of the potential difference (polarity) across the inner mitochondrial
membrane (ΔΨm) determines levels of several mitochondrial activities, including ATP …

Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts

E Samper, DG Nicholls, S Melov - Aging cell, 2003 - Wiley Online Library
Reactive oxygen species are an inevitable by‐product of mitochondrial respiration. It has
been estimated that between 0.4 and 4% of molecular oxygen is converted to the radical …

[HTML][HTML] Effect of oxidative stress on dynamics of mitochondrial reticulum

OY Pletjushkina, KG Lyamzaev, EN Popova… - … et Biophysica Acta (BBA …, 2006 - Elsevier
Fission of the mitochondrial reticulum (the thread–grain transition) and following gathering of
mitochondria in the perinuclear area are induced by oxidative stress. It is shown that …

Measurement of ATP in single oocytes: impact of maturation and cumulus cells on levels and consumption

CM Dalton, G Szabadkai… - Journal of cellular …, 2014 - Wiley Online Library
Mitochondria provide the primary source of ATP in the oocyte and early embryo and
mitochondrial dysfunction and deficit of mitochondria‐derived ATP has been linked to …

Mitochondrial dynamics controlled by mitofusins define organelle positioning and movement during mouse oocyte maturation

T Wakai, Y Harada, K Miyado… - Molecular human …, 2014 - academic.oup.com
Mitochondria are abundant in fully grown mammalian oocytes with a unique spherical
morphology, but the mechanisms controlling mitochondria behavior are not well understood …

Short-and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress

M Jendrach, S Mai, S Pohl, M Vöth, J Bereiter-Hahn - Mitochondrion, 2008 - Elsevier
Cells are exposed during their life span to fluctuating levels of reactive oxygen species
(ROS). To investigate the effects of a single ROS boost in vitro, human endothelial cells …

Obesity-induced oocyte mitochondrial defects are partially prevented and rescued by supplementation with co-enzyme Q10 in a mouse model

CE Boots, A Boudoures, W Zhang, A Drury… - Human …, 2016 - academic.oup.com
STUDY QUESTION Does supplementation with co-enzyme Q10 (CoQ10) improve the
oocyte mitochondrial abnormalities associated with obesity in mice? SUMMARY ANSWER …

[HTML][HTML] Enriched endoplasmic reticulum-mitochondria interactions result in mitochondrial dysfunction and apoptosis in oocytes from obese mice

L Zhao, T Lu, L Gao, X Fu, S Zhu, Y Hou - Journal of animal science and …, 2017 - Springer
Background Maternal obesity alters oocytes and subsequent fetal metabolism. An
increasing number of studies have shown that the endoplasmic reticulums (ER) or …

Differential mitochondrial distribution in human pronuclear embryos leads to disproportionate inheritance between blastomeres: relationship to microtubular …

J Van Blerkom, P Davis, S Alexander - Human reproduction, 2000 - academic.oup.com
It has been suggested that mitochondrial DNA defects that effect metabolic capacity may be
a proximal cause of failures in oocyte maturation, fertilization, or early embryonic …

Effects of myo‐inositol on the in‐vitro maturation and subsequent development of mouse oocytes

TTY Chiu, MS Rogers, C Briton‐Jones… - Human …, 2003 - academic.oup.com
BACKGROUND: The study aim was to assess whether the incorporation of myo‐inositol (MI)
into culture medium could improve oocyte maturation in vitro. METHODS AND RESULTS …