The prevalence of cancer and neurodegenerative diseases, such as Alzheimer's and
Parkinson's, continues to rise worldwide, presenting a significant health burden. Despite …

Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …

Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …

Pyrazolines are five-membered heterocyclic compounds containing two nitrogen atoms that
represent a privileged scaffold for various bioactive compounds with diverse …

Pyridinones have been adopted as an important block in medicinal chemistry that could
serve as hydrogen bond donors and acceptors. With the help of feasible synthesis routes via …

The pyridazine ring is endowed with unique physicochemical properties, characterized by
weak basicity, a high dipole moment that subtends π-π stacking interactions and robust …

Azepane-based compounds showed a variety of pharmacological properties, and its
derivatives possess a high degree of structural diversity, and it is useful for the discovery of …

This chapter contains sections titled: Introduction Project Underpinning Lead Selection:
Structures of HITS and of Proteins Discovery of the Indazole Series Targeting the DFG‐Out …

Pyridine, which is made from unrefined coal tar, has various uses in organic chemistry,
pharmaceutical chemistry, polymers, metal complexes, catalysts, and other fields. Pyridine …

Cancer is a complicated, multifaceted disease that can impact any organ in the body.
Various chemotherapeutic agents have a low selectivity and are very toxic when used alone …