The design and development of a drug is a very long process that generally takes many
years of research. The laborious and expensive drug development pipeline, still …

Epilepsy is one of the most frequent chronic neurological disorder extremely threatening the
life and good health. More than 70 million individuals suffering from epilepsy worldwide and …

In the current study, we designed, synthesized, and characterized a series of substituted
pyrazolo [4, 3-c] pyrazoles. These novel compounds were evaluated in vitro for their …

The phenyl ring is a basic structural element in chemistry. Here, we show the design,
synthesis, and validation of its new saturated bioisostere with improved physicochemical …

Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they
constitute an important class of natural and synthetic compounds exhibiting diverse useful …

Structural changes of small-molecule drugs may bring interesting biological properties,
especially in the field of kinase inhibitors. We sought to study tirbanibulin, a first-in-class dual …

Complex diseases such as neurodegenerative disorders and cancer constitute a growing
public health problem due to the rising incidence and lack in effective therapies. Since …

Acivicin is a natural product with diverse biological activities. Several decades ago its
clinical application in cancer treatment was explored but failed due to unacceptable toxicity …

The pharmacological potential of the pyrazole moiety is demonstrated by their presence in a
wide range of therapeutic agents spanning various categories. Notable examples include …

The pyrazolone structural motif is a critical element of drugs aimed at different biological end-
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …