Five new series of pyrrolo-fused heterocycles were designed through a scaffold
hybridization strategy as analogs of the well-known microtubule inhibitor phenstatin …

Introduction Alzheimer's disease is a multifactorial neurodegenerative disorder
characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The …

There have been continuous efforts to discover multitargeting agents to counter several
complex, multifactorial pathological conditions. Of various heterocycles explored for …

Natural products have always served as an important source of drugs for treating various
diseases. Among various privileged natural product scaffolds, the benzopyrone class of …

This article purposes to provide insights to piperazine based molecular designs that will
facilitate drug discovery program in future. In our pursuit to summarize the reservoir of …

Drug resistance in chronic myelogenous leukemia (CML) requires the development of new
CML chemotherapeutic drugs. Indirubin, a well-known mutikinase inhibitor, is the major …

One can estimate that about 50% of all the drug molecules used in medicine contain a
phenyl ring which can be substituted or not. The bioisosteric replacement of these phenyl …

To obtain new insights into the resistance caused by T315I and the differential selectivities of
dasatinib and axitinib against BCR-ABL1 (WT) and BCR-ABL1 (T315), molecular dynamics …

No drug has been approved to prevent neuronal cell loss in patients suffering from
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …

Multidrug resistance (MDR) is a major obstacle for effective chemotherapeutic treatment of
cancer frequently leading to failure of the therapy. MDR is often associated with the …