Natural products and their derivatives represent a rich source for the discovery and
development of new cancer therapeutic drugs. Bioactive components derived from natural …

The compounds of the quinazoline family belong to the nitrogen-containing heterocyclics;
the core structure represents various biological activities, and many natural compounds are …

Spirocycles are important structural elements, which are frequently used as
pharmacophores and scaffolds in modern drug discovery, offering structural complexity as …

We have developed a series of orally efficacious IRAK4 inhibitors, based on a scaffold
hopping strategy and using rational structure based design. Efforts to tackle low permeability …

Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and
patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter …

Neurodegenerative disorders, ie, Alzheimer's or Parkinson's disease, involve progressive
degeneration of the central nervous system, resulting in memory loss and cognitive …

Alzheimer's disease (AD) is an alarming noncommunicable, multi-factorial, and non-
treatable disease. Its underlying neurodegenerative events have not yet been fully …

Privileged structures can bind to a diverse range of targets with high affinities, thus
benefiting the discovery of novel bioactive agents. 8-Hydroxyquinoline derivatives represent …

Pyrrole is one of the most widely used heterocycles in the pharmaceutical industry. Due to
the importance of pyrrole structure in drug design and development, herein, we tried to …

Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for
the generation of library of enormous lead molecules. Owing to its vast pharmacological …