Replacement of the sulfur atom in biologically active diaryl and heteroaryl thioethers (Ar–S–
Ar', HAr–S–Ar, and HAr–S–HAr') with any of several one-atom or two-atom linkers can be …

Activity-based protein profiling (ABPP) is a versatile strategy for identifying and
characterizing functional protein sites and compounds for therapeutic development …

Background: Privileged structures are potentially able to bind to a diverse range of
biologically important proteins with high affinities, thus benefiting the discovery of novel …

Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …

Azetidines are important motifs in medicinal chemistry, but there are a limited number of
methods for their synthesis. Herein, we present a new method for their modular construction …

Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …

Background: Berberine, which is a naturally occurring alkaloid is widely explored for several
health benefits including for weight management and metabolic disorders. The major …

Alzheimer's disease (AD) remains one of the major neurodegenerative diseases
overwhelming the world today. Alzheimer's is the most complicated as well as perplexing …

Heterocyclic compounds are that type of substances that are deeply intertwined with
biological processes. Heterocycles are found in about 90% of commercially available …

Abstract Imidazo [1, 2-b] pyridazine scaffold represents an important class of heterocyclic
nucleus which provides various bioactives molecules. Among them, the successful kinase …