The emergence of superbugs that are resistant to last-resort antibiotics poses a serious
threat to human health, and we are in a “race against time to develop new antibiotics.” New …

The unmet medical need for the treatment of cancer continues to challenge the biomedical
reearch community. The advent of targeted therapy significantly improved therapeutic …

Pyran is a heterocyclic group containing oxygen that possesses a variety of pharmacological
effects. Pyran is also one of the most prevalent structural subunits in natural products, such …

The discovery of novel synthetic compounds with drug-like properties is an ongoing
challenge in medicinal chemistry. Natural products have inspired the synthesis of …

Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical
structures that confer them with a broad spectrum of pharmacological activities. They have …

The human cannabinoid 2 GPCR (hCB2) is a prime therapeutic target. To define potential
cysteine-related binding motifs critical to hCB2-ligand interaction, a library of hCB2 cysteine …

A convenient synthesis of imatinib, a potent inhibitor of ABL1 kinase and widely prescribed
drug for the treatment of a variety of leukemias, was devised and applied to the construction …

The nitrogen-bearing heterocycle pyridine in its several analogous forms occupies an
important position as a precious source of clinically useful agents in the field of medicinal …

ABL2 (also known as ARG (ABL related gene)) is closely related to the well-studied Abelson
kinase cABL. ABL2 is involved in human neoplastic diseases and is deregulated in solid …

Heterocycles are a cornerstone of fragment-based drug discovery (FBDD) due to their
prevalence in biologically active compounds. However, novel heterocyclic fragments are …