Chronic kidney disease of unknown etiology (CKDu) is a global epidemic. Sri Lanka has
experienced a doubling of the disease every 4 or 5 years since it was first identified in the …

Chronic kidney disease with uncertain etiology (CKDu) in Sri Lanka has attracted much
attention as a global health issue. However, how environmental factors in local drinking …

Background Involvement of agrochemicals have been suggested in the development of
chronic kidney disease of unknown etiology (CKDu). The association between CKDu and …

High-level exposures to a number of agents are known to have direct nephrotoxic effects in
children. A growing body of literature supports the hypothesis that chronic, relatively low …

Chronic kidney disease of uncertain etiology (CKDu) in areas in and around Sri Lanka's
North Central Province has been identified as a major non-communicable disease due to its …

Persistent organic pollutants (POP) occur as mixtures in nature and it is difficult to predict the
toxicity of such mixtures based on knowledge about toxicity and mechanisms of action for …

The acute toxicities and mechanisms of action of a variety of environmental contaminants
were examined using zebrafish larvae (Danio rerio; 4–8 days post fertilization). Toxic …

Introduction As renal development and maturation processes begin in utero and continue
through early childhood, sensitive developmental periods arise during which metal …

As a widely used synthetic pyrethroid insecticide, deltamethrin (DM) causes serious health
problems to aquatic organisms. However, the comprehensive understanding of the adverse …

Chronic kidney disease of unknown etiology (CKDu) is the main health issue in the dry zone
of Sri Lanka. Despite many studies carried out, causative factors have not been identified yet …