Drug addiction is characterized by a set of recurring processes (intoxication, withdrawal,
craving) that lead to the relapsing nature of the disorder. We have used positron emission …

The involvement of dopamine (DA) in drug reinforcement is well established, but much less
in known about its contribution to addiction. We have used positron emission tomography to …

Imaging studies have provided new insights on the role of dopamine (DA) in drug abuse and
addiction in the human brain. These studies have shown that the reinforcing effects of drugs …

The involvement of dopamine in drug reinforcement is well recognized but its role in drug
addiction is much less clear. Imaging studies have shown that the reinforcing effects of drugs …

Imaging studies have revealed neurochemical and functional changes in the brains of drug-
addicted subjects that provide new insights into the mechanisms underlying addiction …

Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we
describe PET imaging studies that investigate dopamine's involvement in drug abuse in the …

Neurophysiologic processes underlie the uncontrolled, compulsive behaviors defining the
addicted state. These “hard-wired” changes in the brain are considered critical for the …

Understanding the changes in the brain which occur in the transition from normal to
addictive behavior has major implications in public health. Here we postulate that while …

Dopamine (DA) is considered crucial for the rewarding effects of drugs of abuse, but its role
in addiction is much less clear. This review focuses on studies that used PET to characterize …

We summarize our studies with positron emission tomography investigating the role of
dopamine (DA) in the reinforcing effects of cocaine and methylphenidate in humans and its …