Reaction products of Pt (meso-diamine) 2+ involving bulky substituted group with DNA were
investigated by using enzymatic digestion technique. Main Pt-adducts were complexes with …

A theoretical study is presented for the binding of RR, SS, SR, and RS isomers1, 2-
diaminocyclohexane (DAC) or c: s-Ptn (DAC) to DNA. ci's-Ptn (DAC) is ligated to N7 (G) on …

The interaction of novel, tetrafunctional bisplatinum compounds with DNA was investigated.
These compounds have bis (vicinal 1, 2-diamines) as ligand. The reactions' efficiency, types …

Dinuclear and trinuclear platinum complexes represent a new class of anticancer agents,
distinct in DNA binding and antitumor activity from their mononuclear counterparts. The first …

Abstract Cis-platinum (II) diamminedichloride (PDD) is one of a group of transitional metal
compounds demonstrated to have antibiotic and antineoplastic effects in vitro [12, 13] and in …

The interaction of cis-and trans-dichlorobis (cyciohexylamine)-, cis-dichlorobis
(cyclopentylamine)-, and cis-dichlorobis (cyclobutylamine) platinumII) with DNA has been …

We have examined the biological activity of 12 platinum (II)-based DNA intercalators of the
type [Pt (IL)(AL)] 2+, where IL is an intercalating ligand (1, 10-phenanthroline or a …

Cisplatin is a simple inorganic compound which has proved to be a very effective anticancer
drug, especially against testicular tumors. The compound has therapeutic limitations based …

Thioether binding mediates monofunctional platinum antitumor reagents to trans
configuration in DNA interactions - Chemical Communications (RSC Publishing) DOI:10.1039/C0CC01408G …

The development of a few worldwide routinely used Pt (II) coordination compounds is
described from a mechanistic point of view and related to the molecular aspects of Pt-DNA …