The adipose tissue is an active endocrine organ that harbours not only mature and
developing adipocytes but also a wide array of immune cells, including macrophages, a key …

In obesity, chronic low-grade inflammation is thought to mediate the effects of increased
adipose tissue mass on metabolic comorbidity. Of the different cell types that contribute to …

Interactions between macrophages and adipocytes influence both metabolism and
inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic …

Chronic, low-grade adipose tissue inflammation is a key etiological mechanism linking the
increasing incidence of type 2 diabetes (T2D) and obesity. It is well recognized that the …

Significance: Obesity and diabetes are associated with chronic activation of inflammatory
pathways that are important mechanistic links between insulin resistance (IR), type 2 …

This review summarizes the role of macrophages in adipose tissue remodeling, particularly
focusing on the paracrine loop between adipocytes and macrophages. The adipose tissue …

It has long been known that adipose tissue in obesity is in a heightened state of
inflammation. Recently, our understanding of this has been transformed by the knowledge …

One decade has passed since seminal publications described macrophage infiltration into
adipose tissue (AT) as a key contributor to inflammation and obesity‐related insulin …

Inflammation originating from the adipose tissue is considered to be one of the main driving
forces for the development of insulin resistance and type 2 diabetes in obese individuals …

The expansion of adipose tissue (AT) in obesity is accompanied by the accumulation of
immune cells that contribute to a state of low‐grade, chronic inflammation and dysregulated …